
From cognitive enhancement to mood support and increased energy levels, methylene blue has gained popularity for its potential physiological benefits.
Originally developed as a dye, methylene blue has since been linked to various health advantages through emerging research.
Today, the market is flooded with methylene blue supplements, offering consumers a wide range of options. With demand on the rise, numerous brands have stepped up to meet the growing interest.
To simplify your search, we’ve thoroughly researched, tested, and compared the most popular methylene blue supplements available. As specialists in the field, we understand what delivers results and what falls short. Here’s what we discovered.
Our Rankings For The Best Methylene Blue Supplements in 2025
Our editorial team spent hundreds of hours researching and testing the best methylene blue supplements. Here are our definitive rankings.
- Earth Harmony Ultimate Methylene Blue
- Fractal Forest Methylene Blue
- Healthletic Methylene Blue
- Tro Just Blue
- MitoZen Lumetol Blue Bars
- Compass Laboratory Methylene Blue
- Biopharm Methylene Blue 1%
- Renue Blue
- 10X Health Methylene Blue Superhuman Energy
Earth Harmony Ultimate Methylene Blue
Earth Harmony offers a range of unique supplements, from Liquid Chlorophyll to a Lymphatic Detox and Drainage Cleanse formula. In recent months, however, the company’s most popular supplement has been Ultimate Methylene Blue.
The USP grade / pharmaceutical grade formula is formaldehyde-free and comes in a glass bottle. Like all reputable methylene blue products, Ultimate Methylene Blue undergoes rigorous testing for consistency and quality. Each 1 mL serving contains around 10mg of the active ingredient.
Fractal Forest Methylene Blue
Fractal Forest’s Methylene Blue aims to enhance cognition, clear brain fog, and keep you sharp and energized. According to Fractal Forest, the active ingredient in Methylene Blue can “donate and accept electrons,” helping to promote various physiological effects.
Taking Fractal Forest’s Methylene Blue daily may optimize brainpower, improve cellular respiration, sustain performance, and help protect cells from oxidative stress, among other benefits.
Like most quality methylene blue supplements, Fractal Forest Methylene Blue contains a single active ingredient: USP-grade blue (Indigofera) that has been lab-tested for purity. Each bottle contains 333mg of methylene blue (1 drop contains 0.5mg). Fractal Forest recommends taking 3 to 10 drops per day with pure water.
Healthletic Methylene Blue
Healthletic’s Methylene Blue is a USP-grade, 99.9% pure, heavy metal-free methylene blue formula with a concentration of 1%.
We like Healthletic’s Ultimate Methylene Blue’s transparent review score: the supplement has an average rating of 4.83 stars out of 5 based on 5,300+ customers. While other manufacturers mindlessly advertise a perfect 5-star rating, Healthletic appears to leave both good and bad reviews online.
Healthletic also seems transparent about the formula’s benefits. Healthletic says Methylene Blue can enhance mood, improve memory, clear brain fog, and boost energy levels. Like other manufacturers, Healthletic publishes its lab test results online to verify that the formula is free of heavy metals and contains the advertised dose of methylene blue.
Tro Just Blue
Just Blue, from Troscriptions Tx (a property of Smarter Not Harder, Inc.), uses the power of methylene blue to boost energy while eliminating inflammation and brain fog.
Each pack is $27 and contains four “troches,” each containing 16mg of pure methylene blue. According to Troscriptions Tx, Just Blue can boost energy and endurance while brightening focus and decreasing inflammation.
Each troche of Just Blue can be split into four parts. The squares easily break apart, allowing you to customize your dose. Most people start with 1/2 troche, for example, of 8mg of methylene blue.
Just Blue contains methylene blue mixed with polyethylene glycol (PEG), stevia extract, lou han extract, peppermint, silica, and Bitter-Bloc, all designed to keep ingredients stable and palatable.
You uniquely use Just Blue: place each troche between your gum and upper check (or you can swallow it on an empty stomach).
- Tro Just Blue Price: $27 (1 Pack / 4 Troches / 16 Doses / 16mg Per Troche)
MitoZen Lumetol Blue Bars
Like Tro Just Blue above, MitoZen’s Lumetol Blue Bars use a unique delivery system, making it more of a hard candy than a liquid formula.
Each bar contains 175mg of methylene blue mixed with various polyphenols or plant-based antioxidants. It’s designed to be taken orally (not as a troche): place the bar in the back of the mouth, then drink it.
One of the advantages of Lumetol Blue Bars’ delivery system is the lack of a blue mouth. Because you place the bar in the back of your mouth and swallow, the supplement never gets the chance to turn your mouth blue.
It is recommended that Lumetol be started with 1/4 or 1/2 square (10 to 20mg). Each square contains 40mg of methylene blue, easily broken into quarters.
- MitoZen Lumetol Blue Bars Price: $89.95 (40mg)
Compass Laboratory Methylene Blue
One of Amazon’s top-rated methylene blue products, Compass Laboratory’s Methylene Blue is a 1% MB formula made in the United States and packaged into a glass bottle.
The USP grade, third-party tested formula claims to promote blood circulation and oxygen flow for overall physical and cognitive energy. Some take it to protect against age-related memory decline. Others take it to promote energy within each cell, revitalizing your energy at the cellular level.
Compass Laboratory Methylene Blue has a 4.4-star out of 5-average rating from verified users on Amazon (1,600+ reviews), making it one of the best-rated formulas on our list. Many users report experiencing significant changes to energy and mental clarity after taking the supplement.
- Compass Laboratory Methylene Blue Price: $30.90 (1.69 fl oz / 50mL)
Biopharm Methylene Blue 1%
Biopharm (BpH) Methylene Blue 1% is a USP-grade methylene blue that offers one of the best values per dose on our list.
A twin pack of glass bottles (50mL per bottle) is priced at $48 and available through Amazon. Each drop (approximately 1mL) of Biopharm Methylene Blue contains around 0.5mg of MB.
Like other reputable manufacturers, Biopharm works with an independent lab to verify the purity and potency of its formula. The company also manufactures methylene blue in the United States.
According to Biopharm, the company’s methylene blue can help with brain performance while supporting antioxidant effects. Some also buy it to prevent fungal disease in aquariums or for general lab use.
- Biopharm Methylene Blue 1% Price: $48 (100mL)
Renue Blue
Renue Blue is the first methylene blue formula on our list. It is designed as a topical serum—not an oral supplement. Instead of swallowing Renue Blue daily, you apply it directly to your skin to promote anti-aging effects from the inside out.
With Renue Blue, you’re applying methylene blue to your body and other active ingredients. The serum features liposomal NAD+, NMN, NR, apocynin, glutathione, and ALA, all popular molecules in the anti-aging community. Some use it as part of the Renue Blue skincare protocol.
To activate these ingredients, apply two pumps of Renue Blue to your face daily. The formula, according to the manufacturer, “works at the cellular level…to improve skin’s texture, firmness, and dermal matrix.”
- Renue Blue Price: $64.95 (1.7 fl oz / 50mL)
10X Health Methylene Blue Superhuman Energy
10X Health offers a popular methylene blue supplement on Amazon. It’s also the only flavored option on our list, available in unflavored or pina colada flavor.
According to 10X Health, Methylene Blue Superhuman Energy can boost energy, enhance focus and cognition, and support overall wellness.
10X Health may be the most celebrity-backed methylene blue brand on our list. For example, NFL legend Ray Lewis is a 10X Health customer and paid ambassador. Professional MMA fighter Michael Chandler also backs the company. 10X Health products have appeared on The Joe Rogan Podcast, The Kardashians, Men’s Health, Maxim, and other major media. Plus, 10X Health was founded by Grant Cardone. The company claims its Methylene Blue Superhuman Energy formula is “what the stars are using.”
- 10X Health Methylene Blue Superhuman Energy Price: $46.25 (1 fl oz)
How We Ranked The Best Methylene Blue Supplements in 2025
Most reputable methylene blue supplements claim to offer “pure” and “high quality” methylene blue. However, not all live up to that claim.
Here are the ranking factors we used to distinguish the best methylene blue supplements from the rest of the pack:
USP / Pharmaceutical Grade
Many top methylene blue supplements are advertised as USP grade or pharmaceutical grade, which means they meet a specific level of purity and potency, maximizing their potential effects. For example, our top-rated methylene blue supplement is Ultimate Methylene Blue, which contains 99.99% USP-grade methylene blue.
Dosage & Concentration
Dosage varies widely between methylene blue products. We judged supplements based on the cost per milligram rather than their concentration. Some supplements, for example, had similar amounts of methylene blue per mg per dollar despite having different volumes and overall price tags. Earth Harmony’s Ultimate Methylene Blue, for example, contains around 10mg of methylene blue in each 1 mL serving.
Glass Bottle
Ideally, methylene blue is stored in a glass bottle for ingredient integrity, which helps keep the active ingredients stable and avoids environmental degradation.
Customer Reviews
Although we tested each methylene blue supplement, we relied on third-party reviews. Generally, customer reviews aligned with the experiences of our editorial team—although there were some outliers. Thousands of five-star reviews from verified users back the best methylene blue products.
Return Policy
Top methylene blue supplement manufacturers are so confident that their products work that they offer a generous money-back guarantee. You can request a refund on your purchase even if the bottle is empty.
Manufacturer Transparency & Reputation
Transparency is essential in a fast-growing industry like methylene blue supplements. Plenty of manufacturers rise and fall while hoping to make a quick buck. We prefer manufacturers with a proven track record of creating practical products, transparent addresses, and contact information.
Added Ingredients
Some methylene blue supplements only contain methylene blue, while others contain various additives to improve taste and texture. Tro Just Blue, for example, creates a hardened candy-like version of methylene blue with a mix of polyethylene glycol (PEG) and stevia extract. Others contain only pure, liquid methylene blue.
Lab Testing & Published CoAs
Certificates of analysis (CoAs) are an easy way for manufacturers to prove their formula contains the active ingredients it’s supposed to contain. Most reputable methylene blue supplement companies listed above publish their CoAs online. These CoAs verify that the formula includes the advertised dose of methylene blue and is free of heavy metals.
Delivery Method, Taste, & Ease of Use
Most methylene blue supplements use a concentrated liquid-based delivery system. Others, like Just Blue, use a buccal troche delivery system. We weren’t biased towards one specific delivery system; however, we preferred delivery systems that were easy to use. Some taste pretty good without using artificial flavors. Others are easy to mix or easy on the stomach.
Advertised Benefits
Methylene blue won’t cure cancer or reverse diseases, so we were wary of manufacturers who made inaccurate claims about its benefits. Per FDA regulations, supplements can’t be marketed to treat, cure, or prevent a disease. That’s why reputable methylene blue companies advertise their products to support energy or promote detoxification.
What is Methylene Blue?
Methylene blue is a special type of salt backed by 130+ years of use in medicinal applications.
The chemical name of methylene blue is methylthioninium chloride. For the last 130+ years, salt has been prized for various benefits.
Due to its distinct blue color, methylene blue was synthesized in 1876 as a textile dye. For example, some early versions of jeans used methylene blue as a coloring agent.
Soon after, however, researchers began to explore the molecule’s medicinal purposes. Starting in the 1880s, researchers used methylene blue to treat malaria.
Sales of methylene blue have surged in the 2020s, and many people take methylene blue daily as a supplement. Some take it for energy, while others for cognition, immune function, anti-aging, or mood.
Methylene blue is also used in specific medicinal applications. The FDA has approved methylene blue to treat methemoglobinemia, a condition linked to oxygen flow in the blood.
Methylene blue’s medicinal applications are so notable that one study described it as “the first fully man-made medicine,” praising the “century-old drug” for promoting anti-aging at the cellular level.
How Does Methylene Blue Work?
Methylene blue has well-known methods of action.
After 130+ years of research, methylene blue is believed to work by promoting three methods of action:
Method of Action #1: Reducing Oxidized Form of Hemoglobin
First, methylene blue appears to work by reducing the oxidized form of hemoglobin to increase its oxygen-binding capacity. That’s a fancy way of saying methylene blue increases oxygen transportation in the blood, making it easier for your body to send oxygen wherever it needs it. This is the primary method of action of methylene blue, and it’s the method of action that led the FDA to approve methylene blue for the treatment and management of methemoglobinemia.
Method of Action #2: Enzyme Inhibition to Promote Blood Flow
Methylene blue also appears to inhibit certain enzymes that boost blood flow. The formula inhibits enzymes like endothelial nitric oxide synthase (eNOS) and guanylate cyclase, which could promote blood flow.
Method of Action #3: Improve Chloroquine Response to Malaria
Methylene blue also appears to improve chloroquine response to malaria by decreasing its resistance, which is why the molecule was initially studied for its effects on malaria prevention.
How to Use Methylene Blue
Depending on your chosen product, there are different ways to use methylene blue.
Some methylene blue supplements are liquid formulas. Others are firm, candy-like products.
Some of the ways to take methylene blue include:
- Always follow the manufacturer’s instructions for dosage and usage
- With liquid methylene blue supplements, you mix drops with water or a beverage of your choice and drink them daily to promote various effects.
- With hard candy-style methylene blue, you can swallow it whole or place it between your gum and cheek (like Tro Just Blue)
- With topical methylene blue formulas, like Renue Blue, apply the formula to your skin as the manufacturer recommends.
- Manufacturers recommend starting with a low dosage before slowly increasing; monitor your body’s response and adjust the dose as necessary.
Is Methylene Blue Legal?
Yes, methylene blue is legal in the United States. The FDA has approved its use for a specific medical condition, and many medical practitioners also use it off-label.
Most methylene blue manufacturers claim to be able to send methylene blue to customers in all 50 states of the United States.
Methylene blue manufacturers report shipping their products worldwide without seizure by customs agencies or law enforcement. Methylene blue is generally believed to be legal in most jurisdictions.
What Does Methylene Blue Do?
People take methylene blue to target a range of physiological effects – from mood to focus to memory to general anti-aging.
Some take methylene blue for a specific reason. Others take it for general health and wellness.
Here are some of the effects of methylene blue, according to the manufacturers listed above:
Boost Energy
Many methylene blue users praise the molecule’s ability to promote energy. Some studies suggest methylene blue boosts energy at the cellular level by enhancing the production of ATP, the primary energy source used by your mitochondria. If your mitochondria, or powerhouses of the cells, aren’t getting the ATP they need, it can make you feel a lack of physical and cognitive energy overall.
Promote Mood Via Dopamine & Serotonin
Some studies suggest methylene blue can influence serotonin and dopamine, two of the most important neurotransmitters for happiness. Your brain uses serotonin and dopamine as reward mechanisms. According to one of the manufacturers listed above (Healthletic), taking methylene blue daily could support “serotonin and dopamine increasing properties. ”
Support Focus
Some find they focus more easily on tasks after taking methylene blue. This effect could be linked to enhanced circulatory health, as the brain can better receive oxygen and blood nutrients after taking methylene blue.
Enhance Overall Cognition & Memory
Beyond focus, methylene blue could support overall cognition and memory. Some find they remember things more quickly after taking methylene blue, for example. Others find they have a better ability to learn information and recall it later – say, for a test.
Promote Anti-Aging
Some claim methylene blue can defend your cells against aging at the cellular level. According to one supplement manufacturer, methylene blue could increase cell longevity, protect against UV exposure, and accelerate wound healing. Your body is constantly being impacted by oxygenation, leading to visible aging. With methylene blue, you could defend your body at the cellular level.
Antioxidant Effects
Methylene blue appears to have natural antioxidant effects. Oxidation is a fancy word for inflammation, a key indicator linked to health problems and disease. Methylene blue appears to battle the free radicals and reactive oxygen species (ROS) that cause inflammation, protecting cells from oxidative damage.
Avoid Burning Mouth Syndrome (BMS)
Interestingly, some use methylene blue to fight back against BMS, or burning mouth syndrome. Burning mouth syndrome is a chronic condition characterized by a burning or tingling sensation around the mouth. There’s no apparent cause for BMS, but some use methylene blue to help manage symptoms.
Support Oxygen Flow to Cells
The more oxygen flows to your cells, the better your overall health. A healthy body sends more oxygen through the blood than an unhealthy body. Blood carries oxygen and nutrients to your cells, which they use for energy. The FDA has approved methylene blue to treat an oxygen-related condition called methemoglobinemia. Oxygen flow is also closely linked to endurance.
Help Defend Against Malaria
In 1891, researchers found methylene blue could help defend against malaria. This discovery proved critical as European empires frequently expanded into malaria-prone parts of the world. Today, the antimalarial effect is linked to the salt’s ability to improve the chloroquine response to malaria by decreasing its resistance.
Other Uses for Methylene Blue
Methylene blue is often taken in supplement form for the benefits above – including its effects on energy, cognition, and overall health.
However, methylene blue has been used for 130+ years for more than just health and wellness. Other uses for methylene blue include:
Clean Fish Tanks
Many are surprised to discover methylene blue is used to clean fish tanks. The same antioxidant effects of methylene blue can clean fungal diseases from aquariums, for example. Some use it at home, while others use it at commercial aquariums to keep tanks clean and healthy.
Blue Dye
Methylene blue is a blue dye used in various applications. In the late 1800s, for example, it was used to make blue jeans. Today, some manufacturers continue to use it as a dye.
Methemoglobinemia Treatment
Methylene blue is typically used as a supplement to support general health. However, the FDA has also approved the use of methylene blue for medicinal purposes—specifically for treating methemoglobinemia. Methemoglobinemia is a health condition where your hemoglobin struggles to carry oxygen. It’s rare, but some take methylene blue to manage it. When used for this purpose, methylene blue is known under Provayblue. It’s also taken via injection—not as an oral supplement.
Medical Imaging
Methylene blue is a blue dye, making it valuable for medical imaging. It is sometimes used to remove polyps because it makes them easy to identify.
Placebo
Interestingly, methylene blue has been used as a placebo in specific trials. The dye makes urine turn blue, convincing users they’re taking an active ingredient to improve their condition, which could make scientific studies more valid.
Septic Shock
Methylene blue has been used to treat septic shock and anaphylaxis. It can also increase blood pressure in certain situations, helping the body manage the shock effects of a serious medical event.
General Lab & Research Use
Methylene blue continues to be studied for various applications in manufacturing, health, and other industries.
Methylene Blue Safety & Side Effects
Methylene blue appears safe for healthy adults to take in recommended doses.
Recent trials on methylene blue have included 2,800+ participants and no reported side effects. Generally, participants experience the active effects of methylene blue without any downsides.
As with any supplement, quality matters: poor-quality methylene blue supplements could contain heavy metals, and those heavy metals could cause side effects or toxification.
Although side effects are rare, side effects of methylene blue should be reported to your doctor as soon as possible and include:
- Chest pain
- Confusion
- Dizziness
- Headache
- Increased sweating
- Stomach pain, nausea, or vomiting
Methylene Blue Interactions
Methylene blue has more interactions than the average supplement. It’s essential to check these interactions or talk to your doctor before taking methylene blue – especially if you are taking medication or have a disease or illness.
Generally, experts recommend avoiding methylene blue or checking with a doctor before taking methylene blue if you have the following conditions:
- Cyanide poisoning
- G6PD deficiency
- Kidney disease
- Allergies to food dyes or preservatives
- Breastfeeding or pregnancy
Some studies suggest methylene blue interacts with bupropion, clomipramine, doxepin, duloxetine, fluoxetine, MAOIs, milnacipran, mirtazapine, rasagiline, selegiline, trazodone, tryptophan, and St. John’s wort, among other medications and supplements.
Scientific Evidence for Methylene Blue
Researchers have studied methylene blue since the 1880s. Over the years, thousands of patients have experienced various benefits linked to methylene blue. We’ll explore the science behind methylene blue below.
One of the most critical studies on methylene blue was published in Cells in 2021 when researchers explored the anti-aging effects of methylene blue. Researchers praised methylene blue for being the “first fully man-made medicine.” Researchers found methylene blue could bypass Complex I / III activity in mitochondria to diminish oxidative stress and help mitigate some effects of aging. Specifically, researchers examined the effects of methylene blue on:
- Neurodegeneration
- Memory loss
- Skin aging
- Progeria (a premature aging disease)
In a similar extensive review on methylene blue, researchers evaluated dozens of trials and decades of research. They found methylene blue had an “extensive safety profile” and promoted various health effects. As proof, researchers identified the molecule’s use in medicine “for decades.” Medical applications of methylene blue have included everything from antimalarial research to surgical imaging.
Methylene blue has surged in popularity over the last decade, partly because of the publication of a 2017 study on its anti-aging effects. In that 2017 study, researchers in China found that methylene blue scavenged free radicals that caused inflammation, helping to promote wound healing, skin thickness, and overall skin appearance.
Unlike many supplement ingredients, the FDA has approved the use of methylene blue to treat methemoglobinemia, a medical condition in which hemoglobin struggles to carry oxygen in the bloodstream.
One of the most recently published studies on methylene blue was released in September 2024. In that open-access study, researchers examined methylene blue in a placebo-controlled setting and found it could be an adjuvant therapy for refractory septic shock.
Methylene blue is backed by decades of research and medicinal use for various purposes, including antimalarial and anti-aging applications.
FAQs About Methylene Blue
We receive plenty of questions about methylene blue and how it works. Below are our most frequently asked questions.
Q: Is Methylene Blue Approved by the FDA?
A: Like all supplements, methylene blue supplements aren’t individually approved by the FDA. However, the FDA has approved methylene blue for the treatment of methemoglobinemia.
Q: What is Methylene Blue?
A: Methylene blue is the common name for methylammonium chloride, a type of salt used in manufacturing and medicine since the 1870s.
Q: What Does Methylene Blue Do?
A: Methylene blue appears to promote the oxygen-carrying capacity of hemoglobin, which could boost energy at the cellular level.
Q: Can Methylene Blue Help Clean My Aquarium?
A: Yes. In addition to being a popular supplement and drug, methylene blue prevents fungal disease in aquariums.
Q: Is Methylene Blue Safe?
A: Methylene blue has been used by thousands of people with no reported side effects and is generally considered safe for healthy adults to take in recommended doses. However, it’s essential to talk to your doctor before taking methylene blue – especially if you are taking medication or have a medical condition – as methylene blue has more contraindications than the average supplement.
Q: Does Methylene Blue Work?
A: Thousands of people use methylene blue supplements daily to promote cognition, physical energy, and overall health and wellness. The molecule has also been studied in formal clinical settings to verify its effects.
Q: Does Methylene Blue Turn My Mouth Blue?
A: Yes, methylene blue supplements tend to turn your mouth blue. Methylene blue was initially created as a manufacturing dye in the 1870s. The dye temporarily stains your mouth and teeth unless you swallow it whole
Q: What’s the Best Methylene Blue?
A: Earth Harmony, Fractal Forest, and Tro make some of the best-rated methylene blue products. Check our list for the full ranking of methylene blue supplements.
Q: How Do I Take Methylene Blue?
A: Methylene blue is typically taken as an oral liquid as a supplement. When taken as medication, however, it’s normally delivered via injection. Some methylene blue supplements also use capsules, tablets, or troches.
Q: What is the Brand Name of Methylene Blue?
A: Methylene blue is known as Provayblue when taken as an injectable medication.
Q: Does Methylene Blue Help With Brain Health?
A: Some studies suggest methylene blue can help with aging and promote overall brain activity. Some take it daily for cognition, memory, and overall brain health.
Q: Is Methylene Blue Natural?
A: No, methylene blue is not natural. It’s a synthetic blue dye. Some have called methylene blue the world’s first ‘man-made’ medicine.
Q: Does Methylene Blue Help With Aging?
A: Some people apply methylene blue to their skin to help with aging, while others take it orally for similar reasons. One study found that methylene blue helped with wrinkles, pigmentation, and wound healing in the skin, while others have reinforced its anti-aging activity.
Q: Does Methylene Blue Help With COVID-19?
A: Methylene blue has been shown to have potent antiviral activity in at least one study. Researchers found that these effects could help with SARS, COVID-19, and H1N1 influenza viruses.
Q: Is Methylene Blue Legal?
A: Yes, methylene blue is legal in the United States. The FDA has approved its use to treat specific health conditions, and it’s also used off-label for other purposes.
Final Word on The Best Methylene Blue Supplements in 2025
Methylene blue has a long history of use in medicine and manufacturing. Today, the ingredient is popular in the supplement community, where many people take it daily for brain health, aging, and physical energy.
To discover the best methylene blue supplements available or to buy methylene blue today, check our list above.
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Disclaimer:
Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have converts following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products have not been confirmed by FDA approved research. These products are not intended to diagnose, treat, cure or prevent any disease.
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